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Gene Knockdown with Small Circular Interfering RNA (sciRNA)

While RNA interference (RNAi) was discovered in 1998, it wasn’t until 2012 when circular RNAs (circRNA) were widely identified in eukaryotic cells. These circRNAs play many regulatory roles in the cell and in recent years have been implicated in muscle development and aging, cardiovascular disease, metabolism, and other diseases. The regulatory abilities of circular RNAs have led to the development of circular RNA towards therapeutic goals and a new gene silencing platform called small circular interfering RNA (sciRNA) has recently been published.

 

This application note provides an overview of gene silencing based on circular RNA, including:

  • The role of circular RNA in eukaryotic cells
  • The design, synthesis, and characterization of sciRNAs
  • The performance of sciRNAs in vitro and in vivo
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